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Anatomy of the human uterus vascular supply with respect to uterus transplantation
Křístek, Jakub ; Froněk, Jiří (advisor) ; Turyna, Radovan (referee) ; Stingl, Josef (referee)
Anatomy of the human uterus vascular supply with respect to uterus transplantation Abstract This dissertation thesis deals with the blood supply of the human uterus and its relevance to uterus transplantation. The first section summarizes what is commonly known of the anatomy of the arterial and venous uterine blood supply including collaterals. It also quotes a few classical anatomical texts, illustrates the transplantation technique, and the pros and cons of utilizing uterine grafts from living and deceased donors. The second section deals with nine publications, the first of which aimed to verify the existence of ipsilateral and contralateral arterial anastomoses. Both types were verified in all specimens (9/9). The second publication analysed two cases of graft thrombosis. The first was brought about through narrowing of the uterine artery, while the other was caused by compression from hematoma. Thrombectomy was unsuccessful in both cases. The third publication compared the utility of CT to that of MR angiography for evaluating uterine vessel quality. These two methods are complementary. The study presents a new radiological classification system suggested to assess uterine vessels. Another publication reports the interim results of a Czech uterus transplant study. Another study presents a uterus...
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Refinement of tissue diagnostics in the transplant program
Balko, Jan ; Zámečník, Josef (advisor) ; Škarda, Jozef (referee) ; Němejcová, Kristýna (referee)
Refinement of tissue diagnostics in the transplant program Abstract The thesis describes tissue diagnostics of organ transplants of the donor as well as recipient. In case of donated organs (grafts), it aims to improve the provisional scoring system of graft rejection after uterine transplantation. Using histopathological methods including immunohistochemistry, it compares lymphocytic population classified in the scoring system with histopathological findings within the resected uteri of women who underwent hysterectomy for benign reasons. The aim was to validate the necessity of the category of so called borderline changes, whose morphology was proven to overlap with physiological finding within healthy uterine cervix. Therefore, there is no need for immunosuppressive therapy in such cases. In case of recipients, the thesis investigates the role of pulmonary megakaryocytes in explanted lungs after transplantation. The idea was to elucidate pathogenesis of the diseases leading to the need of transplantation itself. Pulmonary megakaryocytes within explanted lungs of various recipients were mapped using histopathological methods and immunohistochemistry. The strikingly increased number of such cells was detected among vascular disorders, especially idiopathic pulmonary hypertension. This finding could...
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The Significance of Ultrasound Examination in the Management of Experimental Uterine transplantation
Matěcha, Jan ; Chmel, Roman (advisor) ; Zikán, Michal (referee) ; Roztočil, Aleš (referee)
The significance of ultrasound examination in the management of experimental uterine transplantation Abstract Uterine transplantation (UTx) represents a new experimental method of treatment of absolute uterine factor infertility (AUFI), which includes inability to conceive and deliver as a result of absence of the uterus. This can be congenital (Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS)) or acquired (after hysterectomy, severe congenital uterine malformations). For a woman affected this way is the uterine transplantation the only way to give birth to a child by herself. This is a very sophisticated and invasive procedure for the treatment of sterility with promising results, but the woman - recipient of the uterus - is burdened by at least three abdominal surgeries (transplantation, Caesarean section, explantation), in vitro fertilization and by the need to use immunosuppressive therapy. The dissertation summarizes current knowledge on this issue from the perspective of a gynecologist-obstetrician, who regularly examined by ultrasound or gynecologically participants in the Czech uterine transplant study in 2016-2019, which was carried out on the basis of a cooperation agreement between two Prague hospitals - IKEM and FN Motol. The set contains data on ten patients with a transplanted uterus, five from...
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Uterus transplantation as a path to motherhood
Hlaváčová, Žaneta ; Sokolová, Věra (advisor) ; Hasmanová Marhánková, Jaroslava (referee)
This thesis describes relatively new method of assisted reproduction. Uterus transplantation is viewed from feminist perspective, and its potential benefits and risks in wider ethical and social contexts on theoretical level are being considered. It reveals how womanhood and motherhood are constructed in different discourses in context of uterine transplantation through critical reading and thinking. By using of critical discourse analysis I focus on texts produced on this subject in the popular and professional discourse and reveal what kind of gender stereotypes and constructs they are using to support their arguments. These areas of our everyday lives have great power in society and influence the way we perceive and construct reality and thus participate in its creation. Key words: Uterus transplantation, infertility, motherhood, reproductive technology, gender roles
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